☆強化されたコンボシステム：Spider-Manの特徴的な一連の動き（壁のクロール、ウェブのヤンク、キャプチャウェビングを含む）とともに、Spider-Man 2 for PSPハンドヘルドは、「コクーン」「ヘビーウェブボール」など、さらに多くの操作とコンボをゲームにもたらします。
☆Two years have passed since Peter Parker first hit the streets of New York City as the conflicted crime-fighter Spider-Man. Now he finds himself battling his most diabolical villain yet, the mechanized, multi-tentacled Doc Ock. The nefarious Doc Ock was once Dr. Otto Octavius, a brilliant nuclear physicist. But a freak accident transformed him from a timid researcher to a criminally insane megalomaniac who blames Spider-Man for his horrible transformation. Now the scientist Peter once idolized for his remarkable intellect has marked our web-slinger for death.
☆ As Spider-Man, master new combo moves while you protect the city of Manhattan from the nefarious Doc Ock and other classic Marvel villains. Swing, jump, and wall-crawl through 19 all-new, action-packed levels that extend beyond the film. Experience an unprecedented depth of gameplay as you battle through graphically rich 3D environments.
☆Explore the world of Spider-Man like never before: swing, climb, and web-sling through interactive 3D environments while experiencing scenarios, settings, and characters based on the hit film and others that are exclusive to the game.
☆More Marvel villains: battle even more bosses from Spider-Man's legendary Rogue's Gallery of villains, including Mysterio, Rhino, Shocker, and Vulture.
☆Amazing graphics and depth of gameplay: utilizing the graphical power of the PSP, Spider-Man 2 delivers amazing console-like 3D graphics and incredibly immersive gameplay never before seen in a handheld Spider-Man game.
☆Enhanced combo system: along with Spider-Man's signature set of moves which include wall crawling, web yanking, and capture webbing, Spider-Man 2 for the PSP handheld brings even more maneuvers and combos into the game--such as the "cocoon" and "heavy web ball."